Goutbusters by Michael Spira

Author:Michael Spira
Language: eng
Format: epub
Publisher: Filament Publishing Ltd

FICTION: There are no effective medicines for preventing gout from occurring.

FACT: As you have seen, this is not true. As already discussed, you have Naproxen and Colchicine (Colcrys) for acute gout flare-ups. Then there are the drugs which regulate the levels of uric acid in your blood, such as allopurinol and febuxostat.

THE BOTTOM LINE: Sugar sweetened soft drinks, fructose, fructose rich fruits and fruit juices are associated with an increased risk of gout in men, whereas diet soft drinks are not associated with an increased risk.

Choi HK, Curhan G. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ2008;336:309-12.

Abstract

OBJECTIVE:

To examine the relation between intake of sugar sweetened soft drinks and fructose and the risk of incident gout in men.

DESIGN:

Prospective cohort (medical study) over 12 years.

SETTING:

Health professionals follow-up study.

PARTICIPANTS:

46,393 men with no history of gout at baseline who provided information on intake of soft drinks and fructose through validated food-frequency questionnaires.

MAIN OUTCOME MEASURE:

Incident cases of gout meeting the American College of Rheumatology survey criteria for gout.

RESULTS:

During the 12 years of follow-up, 755 confirmed incident cases of gout were reported.

Increasing intake of sugar sweetened soft drinks was associated with an increasing risk of gout. Compared with consumption of less than one serving of sugar sweetened soft drinks a month, the multivariate relative risk of gout for 5-6 servings a week was 1.29 (95% confidence interval 1.00 to 1.68), for one serving a day was 1.45 (1.02 to 2.08), and for two or more servings a day was 1.85 (1.08 to 3.16; P for trend=0.002).

Diet soft drinks were not associated with risk of gout (P for trend=0.99). The multivariate relative risk of gout according to increasing fifths of fructose intake were 1.00, 1.29, 1.41, 1.84, and 2.02 (1.49 to 2.75; P for trend <0.001).

Other major contributors to fructose intake such as total fruit juice or fructose rich fruits (apples and oranges) were also associated with a higher risk of gout (P values for trend <0.05).

CONCLUSIONS:

Prospective data suggest that consumption of sugar sweetened soft drinks and fructose is strongly associated with an increased risk of gout in men. Furthermore, fructose rich fruits and fruit juices may also increase the risk. Diet soft drinks were not associated with the risk of gout.

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